楊立群
上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院麻醉科
擅長領(lǐng)域:?
執(zhí)業(yè)經(jīng)歷: 職 務(wù):行政副主任 院 區(qū):東院 科 室:麻醉科 教育經(jīng)歷 醫(yī)學(xué)博士 (2007.09-2010.06):第二軍醫(yī)大學(xué)研究生院 麻醉學(xué) 醫(yī)學(xué)碩士 (1998.09-2001.07) 第二軍醫(yī)大學(xué)研究生大隊(duì) 外科學(xué) 醫(yī)學(xué)本科 (1990.09-1995.7) 第二軍醫(yī)大學(xué) 麻醉學(xué) 學(xué)術(shù)職務(wù) ? 2012- 中華醫(yī)學(xué)會(huì)麻醉學(xué)分會(huì)(CSA)全國青年委員、國際講師團(tuán)成員 ? 2009-: 上海市醫(yī)學(xué)會(huì)麻醉專科委員會(huì)(SSA)青年委員及工作秘書 ? 2009-: 上海市醫(yī)學(xué)會(huì)麻醉??莆瘑T會(huì)(SSA) ICU學(xué)組委員 ? 2006-: 美國麻醉醫(yī)師協(xié)會(huì)(ASA) 海外會(huì)員 ? 2013-:國際麻醉藥理學(xué)會(huì)(ISAP)終身委員 2012-: 《Journal of Aneathesia & Clinical Research》編委 2013 第二屆東方麻醉與圍術(shù)期大會(huì)(OCAP2013)會(huì)務(wù)秘書 2011-2012: 第一、二屆全球華人麻醉大會(huì)(GCCA2012)會(huì)議組織者 2011:聯(lián)合麻醉科學(xué)會(huì)議(CSM2011)上海衛(wèi)星會(huì)會(huì)務(wù)及組織者 2009: 2009 全國麻醉學(xué)年會(huì)會(huì)務(wù)秘書(負(fù)責(zé)外賓VIP) 2007-2009: 上海市麻醉學(xué)年會(huì)會(huì)務(wù)秘書 論文著作參編著作 1.器官移植的麻醉 《麻醉學(xué)研究生教材》2014 (中文) 2. 肝P450與麻醉藥代謝 《麻醉與復(fù)蘇新論》. 2001(中文) 3. 靜脈麻醉藥的分子藥理學(xué) 《肝移植》. 2010 (中文) SCI論著 1. Liu YT,Yang LQ,Tao KM, etal. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release.BMC Gastroenterology 2014,14:12 (IF 2.26 co-first author) 2. Yang LQ,Tao KM,Liu YT, et al. Remifentanil Preconditioning Reduces Hepatic Ischemia Reperfusion Injury in Rats via Inducible Nitric Oxide Synthase Expression. Anesthesiology, 2011,114:1036-1047 (IF 5.48, with editorial ) 3. Yang LQ,Tao KM,Cheung CW, et al. The effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients. Anaesthesia 2010,65:1094-1100 (IF 3.08) 4. Yang LQ, Song JC, Irwin MG, et al. A clinical prospective comparison of anesthetics sensitivity and hemodynamic effect among patients with or without obstructive jaundice. Acta Anaesthesiol Scand 2010; 54: 871-7 (IF 2.19) 5. Tao KM, Yang LQ, Liu YT, et al.Volatile anesthetics might be more beneficial than propofol for postoperative liver function in cirrhotic patients receiving hepatectomy. Med Hypotheses 2010,75:555-7. (IF 1.36, Co-first author) 6. Lv X, Yang LQ,Yu WF et al. 1 MAC isoflurane pretreatment on Hepatic Ischemia-Reperfusion in the Rat , role of HO-1. BMC Gastroenterology 2011 (IF 2.47, Co-first author) 7. Tao KM, Tao Y, Chen CY, Yang LQ, Lu ZJ, Sun YM, Huang SD, Yu WF.Proteinase-activated Receptor 1 Contributed to Up-regulation of Enkephalin in Keratinocytes of Patients with Obstructive Jaundice. Anesthesiology. 2014 Mar 7. (IF 5.12) 8. Yang T, Lau WY, Lai EC, Yang LQ, et al. Hepatectomy for bilateral primary hepatolithiasis: a cohort study. Ann Surg 2010; 251: 84-90 (IF 8.46) 9. Li Z, Shi J, Liao Z, Wu FX, Yang LQ, Yu WF. Scientific Publications in Anesthesiology Journals from Mainland China, Taiwan, and Hong Kong: A Ten-Year Survey of the Literature. Anesth Analg. 2010; 110: 918-21. (IF 3.1) 10. Song JC, Zhang MZ, Lu ZJ, Yang LQ,Yu WF. The effects of obstructive jaundice on the pharmacodynamics of propofol: does the sensitivity of intravenous anesthetics change among icteric patients. Acta Anaesthesiol Scand. 2009. 53(10): 1329-35. (IF 2.19) 11. Song JG, Cao YF, Sun YM, Yang LQ Yu WF. Baroreflex sensitivity is impaired in patients with obstructive jaundice. Anesthesiology. 2009. 111(3): 561-5. (IF 5.12) 12. Yu WF, Yang LQ, Zhou MT, et al. Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. World J Gastroenterol 2005;11(32):5025-8 13. Song JG, Cao YF, Yang LQ, et al. Awakening concentration of desflurane is decreased in patients with obstructive jaundice. Anesthesiology. 2005. 102(3): 562-5 (IF 4.56) 14. LQ Yang, Shengjing L, Wei-feng Yu, et al. Potential Inhibition of Cytochrome P450 3A4 by Isopropofol in Human Primary Hepatocytes. World J Gastroenterol 2003;9(9):1959-1962 (IF 2.24) 15. LQ Yang, Wei-feng Y, Shen-Jing L. Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers from patients with chronic liver diseases. World J Gastroenterol 2003;9(2): 359-364 (IF 2.24) 應(yīng)邀講座 1. Liqun Y, Weifeng Y. (2014) Clinical hepato-protection, our recent work. Invite by 韓國麻醉年會(huì) 2. Liqun Y, Weifeng Y. (2009) Obstructive jaundice and anesthesia, our recent work. Invite by 香港麻醉年會(huì). 3. Liqun Y, Weifeng Y.2010 Remifentanil preconditioning attenuate hepatic ischemia reperfusion, 全國中青年麻醉論壇 4. Liqun Y, Weifeng Y, Mengchao W. (2001)Molecular Mechanisms of CYP3A4’s Change in Clinical Hepatobiliary Disease and its Relationship with Metabolism of Anesthetics. 第8屆中日麻醉論壇 5. Liqun Y, Weifeng Y. (2001) Express of CYP3A4 gene in chronic liver disease. 第九屆全軍麻醉會(huì)議 6. Liqun Y, Weifeng Y. (2000) Hepatic cytochrome P450 and metabolism of anesthetics. 第八屆上海市麻醉年會(huì) 課題研究 副高級研究員(2008- Present) at第二軍醫(yī)大學(xué)附屬東方肝膽外科醫(yī)院麻醉與危重病科:研究方向 ? 麻醉藥與肝臟保護(hù) ? 阿片預(yù)處理與肝臟缺血再灌注損傷 助理研究員 (2001-2008) at第二軍醫(yī)大學(xué)附屬東方肝膽外科醫(yī)院麻醉與危重病科:研究方向 ? 慢性肝膽疾患P450改變與麻醉藥分子藥理學(xué) 研究助理 (1996-2001) at第二軍醫(yī)大學(xué)麻醉藥理學(xué)研究室:研究方向 ? 原位肝移植的麻醉藥代動(dòng)力學(xué) ? 國家自然科學(xué)基金NSFC: NO.81471846 (2015-2018): Beta-Arrestin 負(fù)調(diào)控阿片與TLR 通路減輕肝臟IR損傷 (72萬元). ? 國家自然科學(xué)基金NSFC: NO.81272066 (2013-2016): TLR4 參與阿片預(yù)處理抗炎與肝保護(hù)機(jī)制 (70萬元). ? 國家自然科學(xué)基金NSFC: NO.30600584 (2006-2009):CYP3A及MDR1基因多態(tài)性與FK506代謝相關(guān)性研究 (經(jīng)費(fèi) 23萬元). ? 上海市科技啟明星跟蹤計(jì)劃 (No.12QH1402800, 2012-2014): TLR通路調(diào)控阿片預(yù)處理的肝保護(hù)機(jī)制 (經(jīng)費(fèi)20萬元). ? 上海市科技啟明星計(jì)劃 (No.08QA14007, 2008-2010): 新型阿片激動(dòng)劑預(yù)處理的肝保護(hù)機(jī)制 (經(jīng)費(fèi)15萬元). ? 首批上海市優(yōu)秀青年醫(yī)學(xué)人才計(jì)劃 (2005-2008): 來自上海市衛(wèi)生局 (經(jīng)費(fèi)20萬元). 獲得榮譽(yù) 上海市優(yōu)秀博士論文 (2011):瑞芬太尼預(yù)處理的肝保護(hù)機(jī)制研究. 2010全國麻醉中青年論文大獎(jiǎng)賽一等獎(jiǎng): 瑞芬太尼預(yù)處理的肝保護(hù)作用 2002年軍隊(duì)科技進(jìn)步三等獎(jiǎng) : 丙泊酚用于慢性肝病麻醉的基礎(chǔ)與臨床 詳細(xì)介紹
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